RSV Monoclonal Antibody

Hello!

This week I want to discuss the monoclonal antibody Palivizumab. A monoclonal antibody is one that is made by identical immune cells that are clones of a unique parent cell. Palivizumab antibodies bind to the same epitope that immune cells would in targeting the antigenic site of the F protein of RSV. By doing this, it positively affects the innate immune response. The injection Palivizumab is commonly known as Synagis. This injection is given to children to prevent RSV (Respiratory Syncytial Virus).  RSV is a common infection in immunocompromised infants. It causes sloughing of the respiratory epithelium and inflammation of the bronchioles. It typically causes a secondary infection of pneumonia. There is no vaccine but is preventable by Palivizumab. 

According to Mayo Clinic, this injection works by giving your body the necessary antibodies to prevent RSV. This injection keeps RSV cells from multiplying in the blood. It does not work effectively if the child is already infected. The side effects include:

• Runny nose
• Sore throat
• Redness or irritation at injection site
• Vomiting
• Diarrhea

Some more serious side effects include:

• Severe skin rash
• Itching
• Hives (urticaria)
• Difficulty breathing

Most of these are normal and are due to your body adjusting to the medicine; however, it is important to be aware of allergic reactions that could be related to the injection. This drug has been known to cause anaphylaxis in some children, so good communication with your healthcare provider is necessary. The drug does not make you susceptible to other infections. 

The fact that there are injections that can copy your immune cells to deliver a response specifically for the infection you may potentially have is amazing. It is so cool that we have the ability to create immunity. This drug does have to be taken every month for the entire season of RSV. It is important to note that it is not used to treat RSV just to protect against the infection. I think RSV is an interesting infection, and the technology in monoclonal antibodies is pretty remarkable. 

Have a great weekend!!